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Kelch motif : ウィキペディア英語版
Kelch motif


The Kelch motif is a region of protein sequence found widely in proteins from bacteria and eukaryotes. This sequence motif is composed of about 50 amino acid residues which form a structure of a four stranded beta-sheet "blade". This sequence motif is found in between six and eight copies per protein which fold together to form a larger circular solenoid structure called a beta-propeller domain.
==Proteins containing Kelch motifs==
The Kelch motif is widely found in eukaryotic and bacterial species. Notably the human genome contains around 100 proteins containing the Kelch motif. Within individual proteins the motif occurs multiple times. For example, the motif appears 6 times in Drosophila egg-chamber regulatory protein. The motif is also found in mouse protein MIPP and in a number of poxviruses. In addition, kelch repeats have been recognised in alpha- and beta-scruin, in galactose oxidase from the fungus ''Dactylium dendroides'' and in the ''Escherichia coli'' NanM protein, that is a sialic acid mutarotase.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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